Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CALCIUM HYDROXYMETHYLBUTYRATE.

Valuable CAS 35236-72-5 / SKIN CONDITIONING

A sophisticated metabolic derivative of the essential amino acid Leucine, designed to regulate skin protein homeostasis. This bio-active compound serves as a structural fortifier that balances the synthesis of new dermal proteins with the protection of existing cellular architecture.

Summary

Skin conditioning Anti-aging Skin-identical repair Protein synthesis modulator

Science

Mechanism of Action

HMB-Ca functions through a multi-pathway approach: it activates the mTOR signaling pathway to accelerate collagen and elastin secretion while simultaneously inhibiting the ubiquitin-proteasome pathway to prevent protein degradation (anti-catabolism). Furthermore, it stimulates IGF-1 to promote cellular proliferation and supports the synthesis of cholesterol to reinforce the lipid barrier.

Research

Clinical Evidence

High confidence
Effective range 0.5–3%
Optimal

2%

Key findings

  1. 01 Activation of mTOR and IGF-1 pathways for enhanced collagen secretion (Kimura et al., 2014)
  2. 02 Structural integrity and cholesterol synthesis support for barrier repair (Patent CN116018155A)

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Due to its specialized nature and cost, HMB-Ca is often included at 'label-claim' levels. Concentrations below 0.5% are unlikely to trigger the metabolic pathways necessary for significant protein synthesis or barrier fortification.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

The molecule is highly water-soluble but hygroscopic. Formulators must account for calcium ion interference, which can destabilize traditional carbomers or polyacrylate-based gelling agents.

Synergies

  • L-Leucine
  • Peptides
  • Ceramides
  • Hyaluronic Acid

Conflicts

  • Polyacrylate thickeners
  • High-concentration anionic surfactants
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Classified as FDA GRAS for oral consumption, indicating a high biocompatibility profile for topical use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An exceptional signaling molecule for maintaining skin density and preventing the structural degradation associated with aging and environmental stress.

Related

Similar Ingredients

Finding similar ingredients…