Science
Mechanism of Action
This peptide acts as a genomic trigger, upregulating the synthesis of collagen and hyaluronic acid within human fibroblasts. Beyond structural support, it activates the Nrf2 antioxidant pathway and stimulates autophagy—the skin's internal recycling system—to clear damaged proteins and reduce cellular senescence.
Research
Clinical Evidence
High confidence2.8%
Key findings
- 01 In vivo testing on 25 subjects demonstrated a significant increase in skin firmness and elastic response (Ue) after 28 days of twice-daily application at a 2.8% concentration.
Transparency
Dusting Analysis
Because peptides are expensive raw materials, they are frequently included at 'label claim' levels (under 0.1%) which lack the potency to trigger the Nrf2 response or structural protein synthesis seen in clinical trials.
The Formula
Formulation
Stability
Highly stable in aqueous environments within a slightly acidic to neutral range; however, it is vulnerable to degradation by proteolytic enzymes.
Synergies
- Hyaluronic acid
- Non-enzymatic antioxidants
- Other non-proteolytic peptides
Conflicts
- Proteolytic enzymes (Papain, Bromelain)
- Strong oxidizing agents
- Extreme pH environments
Safety
Safety Profile
While the specific calcium salt is not yet indexed by the CIR, Hexapeptide-11 is a well-established cosmetic ingredient with a long history of safe use and is considered GRAS (Generally Recognized as Safe).
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated cell-signaling peptide that effectively bridge the gap between topical hydration and structural dermal repair when used at clinical concentrations.
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