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Moumoujus

CALCIUM GLYCINATE.

Valuable CAS 35947-07-0 / BUFFERING, SKIN CONDITIONING

A sophisticated chelated mineral complex that delivers bioavailable calcium and the amino acid glycine to fortify the skin's architecture. It serves as a precision tool for reinforcing the epidermal barrier and supporting the synthesis of structural proteins.

Summary

Skin conditioning Barrier repair Humectant Buffering agent

Science

Mechanism of Action

It functions by replenishing the 'calcium gradient' within the epidermis, which is critical for regulating keratinocyte differentiation and the assembly of tight junctions. The glycine ligand further enhances the formula as a natural humectant and a primary building block for collagen production, promoting both hydration and dermal density.

Research

Clinical Evidence

High confidence
Effective range 1–3%
Optimal

2%

Key findings

  1. 01 Clinical Human Repeat Insult Patch Tests (HRIPT) at 1% concentration confirm the ingredient is non-sensitizing and non-irritating to human skin.
  2. 02 The 2013 Cosmetic Ingredient Review (CIR) assessment established a 3% threshold as safe for leave-on applications, emphasizing its role in skin conditioning.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.5%

Many formulations include calcium glycinate at trace amounts (<0.5%) for label claims regarding 'mineral-rich' benefits. However, to effectively influence keratinocyte differentiation and provide meaningful barrier support, concentrations should ideally sit between 1% and 3%.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

Possesses superior stability compared to inorganic calcium salts due to its chelated ring structure, which prevents precipitation at neutral pH levels.

Synergies

  • Ceramides
  • Amino acids
  • Peptides
  • Hyaluronic acid

Conflicts

  • Strong chelating agents (e.g., EDTA)
  • High pH environments (>7.5)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
3%
Pregnancy
Safe
Sensitization risk Low

Recognized as safe based on the FDA's GRAS status for glycine salts; it is exceptionally well-tolerated by the skin's biological systems.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An essential mineral for precision barrier maintenance and cellular signaling in mature or compromised skin.

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