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CALCIUM GLYCEROPHOSPHATE.

Valuable CAS 27214-00-2 / 126-95-4 / 1336-00-1 / 58409-70-4 / ANTIPLAQUE, ORAL CARE

A mineral-rich electrolyte complex that serves as a bioavailable source of calcium and phosphorus to reinforce the skin's structural integrity. This multifunctional ingredient stabilizes the acid mantle while enhancing moisture retention and elasticity in high-performance skincare.

Skin-conditioning Buffering agent Humectant Barrier repair Sebum control

Science

It functions via ionic signaling to maintain the epithelial barrier, preserving transepithelial electrical resistance (TEER) even under environmental stress. Beyond its role as a humectant and pH-stabilizing buffer, it acts as a sebum-regulating agent and provides essential minerals for cellular enzymatic processes and healthy skin turnover.


Research

High confidence
Effective range 0.1–5%
Optimal

1%

Key findings

  1. 01 Observed a 15% increase in skin elasticity over 12 weeks of consistent application.
  2. 02 Demonstrated significant preservation of barrier function and reduced permeability under hypoxic stress.

Transparency

Commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Because it is effective at very low concentrations for barrier signaling, brands often include it at negligible levels ('dusting') to claim mineral benefits without achieving the 1.0% threshold required for measurable elasticity improvements.


The Formula

Solubility
Water
Optimal pH 5.5 – 9
0 7 14

Stability

Sparingly soluble in water (1.1%-1.3%); best maintained in neutral to slightly alkaline environments. It is frequently utilized to buffer and stabilize acidic formulas.

Synergies

  • Hyaluronic Acid
  • Peptides
  • Ceramides

Conflicts

  • High-concentration ethanol
  • Strong oxidizing agents
  • Certain anionic surfactants (may cause mineral precipitation)

Safety

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Recognized as GRAS (Generally Recognized as Safe) by the FDA and rated as a low-hazard, irritant-free ingredient suitable for sensitive applications.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated mineral donor that provides essential structural support and pH stability for a resilient, elastic skin barrier.


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