Science
Mechanism of Action
This ingredient functions as a dual-action signal peptide and antioxidant. It stimulates the COL1A1 gene to accelerate Type I collagen synthesis while inhibiting the MMP1 enzymes responsible for breaking down the dermal matrix. Additionally, its caffeoyl moiety neutralizes oxidative stress and prevents glycation, protecting existing proteins from stiffening and loss of function.
Research
Clinical Evidence
High confidence0.05%
Key findings
- 01 Demonstrated a 38.44% increase in collagen-related mRNA expression and a significant reduction in collagen-degrading enzymes in human fibroblast models.
- 02 Proven effective for wrinkle depth reduction and skin tone brightening through enhanced transdermal delivery systems.
Transparency
Dusting Analysis
Because this peptide is effective at concentrations as low as 0.05%, brands often include it at trace levels (below 0.001%) just for label claims. For meaningful clinical results in collagen synthesis, a concentration of at least 0.05% is recommended.
The Formula
Formulation
Stability
Requires a neutral environment; it is susceptible to degradation in highly acidic or alkaline formulas. Stability is significantly enhanced when encapsulated in lipid-based delivery systems like nanoethosomes.
Synergies
- Liposomal delivery systems
- Hydrating humectants
- Other non-acidic antioxidants
Conflicts
- Strong AHAs/BHAs (low pH)
- Proteolytic enzymes
- High thermal processing (>70°C)
Safety
Safety Profile
Recognized by the EU CosIng database; its peptide structure ensures high biocompatibility and low irritation potential even in sensitive applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, multi-functional peptide that offers measurable improvements in skin density and tone when formulated within its stable pH window.
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