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CAFFEOYL TRIPEPTIDE-34.

Valuable / SKIN CONDITIONING

A high-performance hybrid peptide that fuses the structural repair capabilities of a tripeptide with the potent antioxidant properties of caffeic acid. This engineered molecule targets both the visible signs of aging and the underlying inflammatory triggers that lead to skin degradation and uneven tone.

Skin conditioning Antioxidant Anti-aging Anti-inflammatory

Science

This dual-action peptide functions via three distinct biological pathways: it neutralizes reactive oxygen species (ROS) through its caffeic acid moiety, modulates inflammatory markers to enhance melanocyte tolerance and prevent hyperpigmentation, and reinforces the extracellular matrix by stimulating collagen and elastin production while simultaneously inhibiting the enzymes that break down the skin's structural proteins.


Research

High confidence
Effective range 1–5%
Optimal

3%

Key findings

  1. 01 Clinical evaluations of formulations containing this peptide complex demonstrated significant improvements in skin density and a visible lifting effect on sagging tissue within 14 to 28 days.
  2. 02 Professional-grade trials verified the ingredient's safety and non-irritating nature even when applied to compromised skin following microneedling procedures.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.5%

Because this is a specialized, high-cost hybrid peptide, it is often included at sub-clinical levels (below 1%) purely for marketing claims. Efficacy for lifting and density is typically documented at concentrations between 1% and 5%.


The Formula

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

Highly stable for 3 years in original packaging via protein stabilization technology; however, once formulated into aqueous solutions, refrigeration is recommended to preserve the integrity of the peptide bond.

Synergies

  • Other bioactive peptides
  • Hyaluronic acid
  • Niacinamide

Conflicts

  • Strong acids
  • Strong bases
  • Proteolytic enzymes
  • Strong oxidizing agents
  • Excessive heat

Safety

CIR Status
Not yet reviewed by CIR
Pregnancy
Safe
Sensitization risk Low

Extensively utilized in professional dermatological and post-procedure products with a recorded history of being hypoallergenic and non-irritating.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptional multi-tasking peptide that provides rapid results for skin firming and structural density while maintaining high compatibility with sensitive and post-procedure skin.


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References