Science
Mechanism of Action
This peptide acts as a dual-action biological modifier: it mimics thymopoietin to stimulate TGF-beta, which triggers the endogenous production of structural proteins, while simultaneously inhibiting MMP-9 enzymes to prevent collagen degradation. Additionally, its caffeic acid component functions as a targeted antioxidant, neutralizing free radicals and suppressing UVB-induced inflammatory markers like IL-8.
Research
Clinical Evidence
High confidence0.0025%
Key findings
- 01 Observed significant acceleration in keratinocyte and fibroblast proliferation alongside a 37.6% reduction in MMP-9 expression.
- 02 Demonstrated a substantial increase in endogenous collagen synthesis within 48 hours of application.
Transparency
Dusting Analysis
Because this peptide is effective at parts-per-million (ppm) levels, brands often list it at the very end of the INCI list to claim anti-aging benefits without reaching the 10-25 ppm threshold required for physiological collagen induction.
The Formula
Formulation
Stability
The conjugation with caffeic acid enhances the molecule's resistance to browning and oxidation compared to standalone caffeic acid, though it remains sensitive to extreme pH levels.
Synergies
- Vitamin C
- Hyaluronic Acid
- Niacinamide
- Other Signal Peptides
Conflicts
- Strong oxidizing agents
- High-percentage AHAs (pH < 3.5)
- Strongly alkaline formulations (pH > 8.0)
Safety
Safety Profile
Listed in the EU Glossary of Cosmetic Ingredients; manufacturer tests confirm zero cytotoxicity up to 1,000 ppm, which is significantly higher than standard usage rates.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptionally stable and multifunctional peptide that provides both immediate antioxidant defense and long-term structural support for aging skin.
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