Science
Mechanism of Action
This peptide functions as a Leu-Enkephalin biomimetic, effectively calming neurogenic inflammation and sensitivity caused by external triggers like temperature shifts. Simultaneously, it neutralizes free radicals and inhibits tyrosinase to prevent hyperpigmentation, while stimulating the synthesis of essential extracellular matrix proteins to improve skin density.
Research
Clinical Evidence
High confidence1e-7%
Key findings
- 01 A 4-week in-vivo study at a concentration of 1 ppb (0.0000001%) demonstrated a 14.2% reduction in smile lines, 11.1% reduction in forehead wrinkles, and 7.3% improvement in the periorbital area.
- 02 Comparative testing indicates superior melanin suppression and tyrosinase inhibition when measured against traditional Arbutin.
Transparency
Dusting Analysis
Due to its extreme potency at the parts-per-billion (ppb) level, traditional 'dusting' metrics are difficult to apply; however, clinical efficacy is established at remarkably low thresholds, making it a highly efficient active even in trace amounts.
The Formula
Formulation
Stability
Highly stable in aqueous solutions within acidic to neutral ranges. It is thermolabile and should not be exposed to temperatures exceeding 40°C during manufacturing.
Synergies
- Hyaluronic acid
- Niacinamide
- Non-proteolytic peptides
Conflicts
- Proteolytic enzymes
- Strong oxidizing agents
- Strong reducing agents
- High alkaline environments (pH > 8.0)
Safety
Safety Profile
Follows the standard safety profile of synthetic peptides; generally recognized as non-irritating and safe for long-term cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, multifunctional neuropeptide that offers measurable wrinkle reduction and brightening benefits at exceptionally low concentrations.
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