Science
Mechanism of Action
This ingredient functions through a dual-action pathway: the sh-Decapeptide-23 component acts as an Angiotensin I mimic to signal regenerative skin repair, while the Caffeic Acid moiety scavenges reactive oxygen species (ROS). It further protects the extracellular matrix by inhibiting Matrix Metalloproteinases (MMPs) that break down collagen and by suppressing the NF-κB inflammatory signaling pathway.
Research
Clinical Evidence
Medium confidence0.01%
Key findings
- 01 Manufacturer-led efficacy testing demonstrates significant reduction in oxidative stress markers and improved skin barrier resilience upon application.
Transparency
Dusting Analysis
Because peptides are active at parts-per-million (ppm) levels, brands often list them at the bottom of the INCI to claim benefits without including enough to trigger cellular signaling. Effective formulations should contain at least 1-5 ppm (0.0001% - 0.0005%) of the pure peptide.
The Formula
Formulation
Stability
Thermolabile; must be incorporated during the cool-down phase below 40°C to prevent peptide bond hydrolysis. Highly sensitive to extreme pH shifts.
Synergies
- Hyaluronic Acid
- Niacinamide
- Non-proteolytic growth factors
Conflicts
- Strong oxidizing agents
- Strong acids
- Strong bases
- Proteolytic enzymes (Papain, Bromelain)
Safety
Safety Profile
Synthetic peptides of this class exhibit high biocompatibility and low transdermal toxicity, making them suitable for long-term use in precision skincare.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An innovative hybrid peptide that offers sophisticated antioxidant protection and repair signaling, though more independent clinical data would solidify its status as a top-tier active.
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