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CAFFEOYL OLIGOPEPTIDE-77.

Valuable / SKIN CONDITIONING

A high-performance conjugated peptide that merges the antioxidant power of caffeic acid with a targeted amino acid sequence to refine skin texture. It is engineered specifically to address the dual needs of pore structural integrity and oil-moisture equilibrium.

sebum regulation pore refinement collagen stimulation anti-aging

Science

This peptide acts as a biomimetic signaling molecule that upregulates COL1A1 mRNA expression, stimulating the production of Type I Collagen to reinforce the dermal matrix surrounding pores. Simultaneously, it modulates sebocyte activity to decrease excess oil production, leading to visibly tighter pores and a matte, yet hydrated, finish.


Research

Medium confidence
Effective range 0.0001–10%
Optimal

0.05%

Key findings

  1. 01 In-vitro data showed significant induction of Type I collagen synthesis and a measurable reduction in sebum output.
  2. 02 Human trials conducted over 4 weeks demonstrated substantial improvements in wrinkle depth and skin elasticity.

Transparency

Commonly dusted
Min. effective
0.05%
Red flag below
0.001%

Because peptides are effective at very low concentrations, brands often include them at 'label-only' levels (e.g., 0.0001%) to claim anti-aging benefits. For genuine pore-refining and sebum-regulating results, concentrations closer to 0.05% are recommended.


The Formula

Solubility
Water
Optimal pH 6 – 7.5
0 7 14

Stability

Maintains stability for 30 days at 45°C in optimized systems; however, it is highly sensitive to proteolytic enzymes and extreme pH shifts. Delivery is often enhanced via ethosomal encapsulation.

Synergies

  • Niacinamide
  • Hyaluronic Acid
  • Antioxidants

Conflicts

  • Strong Alpha Hydroxy Acids
  • Strong bases
  • Proteolytic enzymes (Papain, Bromelain)
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Generally regarded as safe based on the inherent profile of peptides; patent-specific safety testing indicates a lack of irritation at recommended usage levels.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An innovative, multifunctional peptide that offers a sophisticated scientific solution for simultaneously managing oil production and structural skin aging.


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