Science
Mechanism of Action
This peptide functions as a specific agonist for delta-opioid receptors in the skin, modulating the biological response to inflammatory stress. It promotes structural resilience by upregulating COL1A1 (collagen) mRNA expression while simultaneously inhibiting MMP1, the enzyme responsible for breaking down the extracellular matrix.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 In vitro studies on nHDFs demonstrate significant regulation of collagen-related genes and inhibition of matrix metalloproteinase-1.
- 02 Clinical industry data suggests inclusion levels of 0.1% to 2% within peptide complexes effectively reduce stress-induced skin aging and improve brightening.
Transparency
Dusting Analysis
Due to its high cost and efficacy at low concentrations, this ingredient is frequently included in 'label-only' amounts. While bioactive at very low levels in cellular studies, a concentration of at least 0.1% is typically required for meaningful anti-aging and receptor-modulation claims in finished products.
The Formula
Formulation
Stability
Highly stable in aqueous solutions within the neutral pH range. It is sensitive to high-temperature processing and should be incorporated during the cooling phase of production.
Synergies
- Ethosomes
- Liposomes
- Hyaluronic Acid
- Niacinamide
Conflicts
- Strong oxidizing agents
- Strong acids (pH < 4.0)
- Strong bases (pH > 9.0)
Safety
Safety Profile
Listed in the EU CosIng database as a safe antioxidant; peptides are generally non-sensitizing and well-tolerated by most skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, low-irritancy peptide that provides essential protection against stress-induced aging when formulated at therapeutic concentrations.
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References
Sources