Science
Mechanism of Action
This ingredient functions as a high-affinity antioxidant by neutralizing DPPH, hydroxyl, and peroxyl radicals. By linking caffeic acid to the APPPKK peptide sequence, it achieves superior cellular delivery, where it inhibits the production of nitric oxide (NO) to reduce inflammation and prevents DNA damage and lipid peroxidation caused by hydrogen peroxide exposure.
Research
Clinical Evidence
Medium confidence0.007%
Key findings
- 01 In vitro analysis (Lee et al., 2017) demonstrated that at a 100 μM concentration (0.007%), the peptide achieved 87.3% radical scavenging activity and significant suppression of inflammatory markers while maintaining over 90% cell viability.
Transparency
Dusting Analysis
Because this peptide is bioactive at extremely low concentrations (parts per million), many formulations include it at 'label-only' levels. For meaningful antioxidant protection, it should be present at or near the 0.007% (70 ppm) concentration used in primary research.
The Formula
Formulation
Stability
The conjugation process significantly improves the water solubility and oxidative stability of caffeic acid, preventing the common browning and degradation often seen with free phenolic acids.
Synergies
- Vitamin C
- Hyaluronic acid
- Niacinamide
Conflicts
- Strong oxidizing agents
- Strong acids
- Strong bases
- Proteolytic enzymes
Safety
Safety Profile
As a relatively recent biotech innovation, it lacks a formal CIR review, but initial toxicological data shows high cell viability and low irritation potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, high-stability antioxidant peptide that offers precise protection against environmental DNA damage and inflammation.
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