Science
Mechanism of Action
This peptide functions as a cell-communicating agent that accelerates fibroblast regeneration and stabilizes keratinocyte proliferation. By suppressing pro-inflammatory cytokines and inducing angiogenic growth factors like VEGF and PDGF, it simultaneously restores the skin barrier, reduces allergic responses, and promotes hair follicle vitality.
Research
Clinical Evidence
High confidence0.05%
Key findings
- 01 In vitro analysis revealed that a 0.05% concentration boosted COL1A1 (Collagen 1) expression by 38.44% while inhibiting collagen-degrading MMP1 enzymes by 21.05%.
- 02 In vivo testing at 25 ppm demonstrated hair growth stimulation and thickness improvements comparable to 2.5% Minoxidil through the activation of bFGF and PDGF-A growth factors.
Transparency
Dusting Analysis
Because this peptide is effective at extremely low parts-per-million (ppm) levels, brands often include it at negligible concentrations for marketing claims. Efficacy for collagen synthesis requires at least 0.05%.
The Formula
Formulation
Stability
Highly resilient in aqueous and hydrogel systems; maintains integrity for 30 days at 45°C when utilized in ethosome delivery complexes. Store between 2-30°C.
Synergies
- Hyaluronic acid
- Niacinamide
- Other non-proteolytic peptides
Conflicts
- Proteolytic enzymes
- Strong oxidizing agents
- pH levels below 4.0 or above 8.0
Safety
Safety Profile
Classified as Generally Regarded as Safe (GRAS) with no observed cytotoxicity in manufacturer testing up to 500 ppm.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional multi-target peptide that delivers significant collagen-modulating and anti-inflammatory benefits when formulated at clinically active concentrations.
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References
Sources