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CAFFEOYL DIPEPTIDE-25 AMIDE.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

A cutting-edge hybrid peptide that chemically fuses the antioxidant power of caffeic acid with the precision signaling of Dipeptide-25. This bio-active molecule is engineered to target both pigment production and inflammatory aging, making it a sophisticated choice for advanced radiance-correcting formulas.

Brightening Antioxidant Skin Conditioning Anti-Inflammaging

Science

This ingredient operates via a dual-action pathway: it serves as a potent tyrosinase inhibitor to block melanin synthesis at the source, while simultaneously acting as a reactive oxygen species (ROS) scavenger to mitigate 'anti-inflammaging'—the process where environmental stress triggers premature skin degradation.


Research

High confidence
Effective range 0.001–3%
Optimal

1.5%

Key findings

  1. 01 In-vitro patent testing demonstrated significant melanin reduction at concentrations as low as 10-1000 ppm, outperforming pure caffeic acid.
  2. 02 8-week clinical trials using standardized 1-3% solutions showed measurable improvements in skin luminosity and a reduction in localized hyperpigmentation.

Transparency

Commonly dusted
Min. effective
0.001%
Red flag below
0.0001%

Because this peptide is efficacious at extremely low parts-per-million (ppm), it is often 'dusted' into formulas at negligible levels for marketing purposes. For true corrective results, we look for concentrations aligned with clinical supplier data (0.1% to 3%).


The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Heat sensitive; must be integrated during the cooling phase below 40°C to maintain peptide integrity. Stable in standard storage when kept within physiological pH ranges.

Synergies

  • Niacinamide
  • Vitamin C derivatives
  • Hyaluronic Acid

Conflicts

  • Strong oxidizers
  • Proteolytic enzymes
  • Extreme pH environments (<3.0 or >9.0)

Safety

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

While not yet formally reviewed by the CIR, its constituent parts (caffeic acid and amino acids) have well-established safety profiles in cosmetic use.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A high-performance, multifunctional peptide that offers a precise solution for both environmental protection and pigment correction.


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