Science
Mechanism of Action
The ingredient functions as a permeable carrier system where the Tripeptide-37 sequence facilitates the penetration of caffeine across the stratum corneum. Once active, the caffeine stimulates lipolysis to reduce adipose-related puffiness and improves microcirculation, while the peptide mimics Thrombospondin-1 (TSP-1) to activate latent TGF-β1, resulting in the significant up-regulation of Collagen I, Collagen III, and Elastin.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 In-vivo trials using 1-3% concentrations demonstrated a visible reduction in skin age of up to 8 years within 42 to 56 days of consistent application.
- 02 Significant improvements recorded in under-eye bag volume, skin elasticity, and the depth of fine lines.
Transparency
Dusting Analysis
As a relatively new and high-cost conjugated peptide, there is a risk of 'label dressing' at levels below 0.5%. Efficacy for both de-puffing and collagen synthesis is clinically validated starting at 1% of the active supplier blend.
The Formula
Formulation
Stability
Thermolabile; must be incorporated during the cool-down phase at temperatures below 40°C. Maintain a neutral to slightly acidic pH to prevent peptide hydrolysis.
Synergies
- Hyaluronic Acid
- Niacinamide
- Other signal peptides
Conflicts
- Strong acids
- Strong bases
- High electrolyte concentrations
Safety
Safety Profile
Generally regarded as non-toxic and non-sensitizing. Its targeted delivery mechanism minimizes the systemic absorption often associated with high-dose caffeine.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated, multi-functional peptide hybrid that offers superior caffeine delivery and proven structural rejuvenation for aging or fatigued skin.
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References
Sources