Science
Mechanism of Action
Provides branched C10-40 iso-fatty acids that structurally mimic the skin's natural 18-MEA lipids, integrating into intercellular lipid lamellae to restore barrier integrity, reduce transepidermal water loss, and create lipid pathways that enhance active ingredient delivery into the stratum corneum
Research
Clinical Evidence
Medium confidence2.5%
Key findings
- 01 Enhanced penetration system efficacy at 0.5-5% concentration, improving active delivery by mimicking lipid matrix structure
- 02 Significant barrier repair and TEWL reduction at 1-10% through iso-fatty acid replenishment
Transparency
Dusting Analysis
Functional concentrations begin at 0.5% for penetration enhancement, with meaningful barrier repair requiring 1%+ levels; sub-1% usage likely represents token inclusion
The Formula
Formulation
Stability
Excellent stability in anhydrous and standard emulsion systems; vulnerable to hydrolysis below pH 3.0 or above pH 8.0, especially under heat
Synergies
- ceramides
- cholesterol
- other barrier lipids
Conflicts
- strong oxidizing agents
- highly alkaline ingredients
Safety
Safety Profile
CIR-assessed as part of triglycerides and glyceryl esters groups in 2017, deemed safe when formulated to avoid irritation
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically sophisticated barrier-repair ingredient that delivers targeted lipid restoration for compromised or aging skin when used at meaningful concentrations.
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