Science
Mechanism of Action
Functions through multiple pathways including ROS scavenging via flavonoids and tannins, cellular autophagy modulation through steroidal alkaloids (buxine, cyclobuxine), and inflammatory pathway inhibition. The extract promotes cellular detoxification and renewal by enhancing autophagic flow in skin fibroblasts, while simultaneously providing antimicrobial protection against various pathogens.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro research at 32-72 μg/mL demonstrated cellular proliferation inhibition and enhanced autophagic flow in skin fibroblasts, indicating therapeutic potential for hyperproliferative skin conditions
- 02 Antioxidant efficacy confirmed through significant reduction in lipid peroxidation and free radical scavenging activity in controlled studies
Transparency
Dusting Analysis
No evidence of dusting practices found in commercial formulations, typically used in meaningful concentrations due to its active botanical compounds
The Formula
Formulation
Stability
Maintains stability in both hydroalcoholic and aqueous systems but requires temperature control below 58°C to preserve peroxidase enzymes and antioxidant capacity
Conflicts
- Strong oxidizing agents
- Strongly alkaline formulations (pH >7) may precipitate alkaloids
Safety
Safety Profile
While alkaloids render internal use toxic, topical application in diluted extract form demonstrates safety in commercial cosmetic applications globally. No CIR review available but widespread commercial use suggests acceptable safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed botanical extract offering unique cellular regulation benefits through autophagy modulation, making it particularly valuable for comprehensive anti-aging and skin health formulations.
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References
Sources