Science
Mechanism of Action
Functions as a cell-communicating signal peptide that mimics endogenous collagen fragments to trigger skin's repair response. Stimulates extracellular matrix regeneration in mature skin, reinforces dermal-epidermal structural integrity, and enhances skin elasticity through targeted protein building block communication.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Patent study at 0.1-1.0% demonstrated significant skin renewal improvement, early line reduction, and measurable wrinkle depth decrease in mature skin
- 02 Multi-peptide complex study at 0.001% showed enhanced skin condition maintenance and natural repair support
Transparency
Dusting Analysis
Effective concentrations start at 0.001% for maintenance effects, with therapeutic benefits at 0.1%+. Concentrations below 0.005% likely provide minimal matrix regeneration benefits.
The Formula
Formulation
Stability
Highly stable in aqueous systems. Must be incorporated during cooling phase below 40°C to preserve peptide bond integrity and prevent thermal degradation.
Synergies
- Other peptides
- Hyaluronic acid
- Antioxidants
Conflicts
- Strong oxidizing agents
- Proteolytic enzymes
- Extreme pH formulations
Safety
Safety Profile
While not individually assessed by CIR, pentapeptides as a class demonstrate excellent safety profiles with minimal sensitization potential in cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Well-researched signal peptide with proven matrix regeneration benefits and excellent safety profile across all skin types.
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References
Sources