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Moumoujus

BUTYROYL GLUTATHIONE.

Valuable CAS 690633-16-0 / ANTIMICROBIAL, ANTIOXIDANT, REDUCING

A lipophilic derivative of glutathione engineered for enhanced skin penetration and stability. This modified tripeptide delivers powerful antioxidant protection while addressing inflammation and uneven skin tone. Clinical studies demonstrate efficacy at concentrations as low as 0.4% for inflammatory conditions.

Summary

antioxidant antimicrobial reducing agent anti-inflammatory skin brightening

Science

Mechanism of Action

Functions as a cellular antioxidant by inhibiting lipid peroxidation and replenishing intracellular glutathione stores. Reduces inflammatory cytokine expression (IL-6, IL-8) through NF-κB pathway modulation. Achieves skin brightening via tyrosinase inhibition through antioxidant activity, copper chelation, and melanosome transport disruption.

Research

Clinical Evidence

Medium confidence
Effective range 0.4–2%
Optimal

0.4%

Key findings

  1. 01 Significant reduction in inflammatory lesions, erythema, and scaling in seborrheic dermatitis patients with high tolerability
  2. 02 Significant reduction in UV-induced erythema (p=0.0003) and improved skin brightness through melanin index reduction

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Clinical efficacy demonstrated at 0.4%, making concentrations below 0.1% likely insufficient for meaningful antioxidant and anti-inflammatory benefits

The Formula

Formulation

Solubility
Both
Optimal pH 4.5 – 5.5
0 7 14

Stability

Enhanced stability compared to pure glutathione due to butyryl esterification protecting against autoxidation. Susceptible to hydrolysis at pH extremes.

Synergies

  • Hyaluronic Acid

Conflicts

  • Strong oxidizing agents
  • Highly alkaline ingredients (pH > 7.0)
  • Strong acids

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Clinical studies report non-toxicity to human fibroblasts and excellent tolerability up to 2% without irritation or cytotoxicity

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A scientifically-backed antioxidant with demonstrated clinical efficacy for inflammation and brightening at reasonable concentrations.

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