Science
Mechanism of Action
Functions through dual pathways: neutralizes reactive oxygen species via high concentrations of tannins and flavonoids, while triterpenoids (ursolic and oleanolic acids) inhibit inflammatory NF-kB and MAP kinase pathways and stimulate cellular repair mechanisms for enhanced barrier function.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 Demonstrated significant antioxidant activity and free-radical scavenging capacity in DPPH assays
- 02 Showed antimicrobial synergy against MRSA by targeting cell-wall resistance mechanisms
Transparency
Dusting Analysis
Effective concentrations start at 0.03 mg/mL with therapeutic benefits demonstrated up to 2.8%, making token amounts below 0.05% unlikely to provide meaningful antioxidant or barrier-repair benefits.
The Formula
Formulation
Stability
Highly photosensitive and thermally unstable; requires antioxidant protection (Vitamin E) and opaque packaging to prevent degradation
Synergies
- Vitamin E
- other antioxidants
Conflicts
- Strong oxidizing agents
- Strongly alkaline environments
Safety
Safety Profile
While related shea-derived ingredients received CIR safety approval in 2017, leaf extract was not included in that specific assessment bundle.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A well-researched botanical extract offering genuine antioxidant and barrier-repair benefits across all skin types, though formulation stability requires careful consideration.
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