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BUTYLQUINOLINE.

Valuable CAS 53452-65-6 / PERFUMING

A multifunctional quinoline derivative that serves dual roles as a sophisticated fragrance compound and antimicrobial agent. Beyond its distinctive leathery-woody aromatic profile, it demonstrates clinically-proven efficacy in controlling odor-causing bacteria on skin. This chemaesthetic ingredient can also stimulate trigeminal nerve receptors, creating subtle warming sensations.

perfuming antimicrobial chemaesthetic

Science

Functions through bacterial growth inhibition, specifically targeting gram-positive microorganisms like Corynebacterium xerosis and Staphylococcus epidermidis that decompose sweat into malodorous compounds. As a weak base with pKa ~5.2, it maintains optimal antimicrobial activity in neutral to slightly acidic skin environments while remaining lipophilic and unprotonated.


Research

Medium confidence
Effective range 0.05–1%
Optimal

0.3%

Key findings

  1. 01 Human in vivo sniffing tests at 0.3% concentration demonstrated significant body odor reduction in deodorant formulations
  2. 02 In vitro antimicrobial testing at 0.05-1.0% showed strong inhibitory activity against primary odor-forming skin bacteria

Transparency

Not commonly dusted

Primarily used as a specialized fragrance and antimicrobial ingredient in targeted applications rather than being added for marketing appeal


The Formula

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Exhibits excellent stability under standard storage conditions with resistance to pH extremes, though performance optimization occurs in neutral to slightly acidic formulations

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong alkalis

Safety

CIR Status
Not reviewed
Max tested
1.2%
Sensitization risk Low

RIFM assessment confirms non-genotoxic and non-clastogenic properties. Registered in FDA Global Substance Registration System (UNII: K0BBK7OARM)


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A scientifically-backed dual-purpose ingredient offering both sophisticated fragrance notes and proven antimicrobial benefits for odor control applications.


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