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BUTYLPHENYL METHYLPROPIONAL.

Avoid CAS 80-54-6 / FRAGRANCE, PERFUMING

A synthetic aromatic aldehyde traditionally used for its distinctive lily-of-the-valley fragrance in cosmetic formulations. This ingredient has been classified as a Category 1B reproductive toxicant and potent contact allergen, leading to its prohibition in the European Union since March 2022.

perfuming

Science

Functions as a hapten that oxidizes to lysmerylic acid upon skin contact, binding to skin proteins and potentially triggering Type IV delayed hypersensitivity reactions. Systemically acts as a potential endocrine disruptor with androgen receptor agonist properties.


Research

High confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted
Red flag below
0.001%

Must be declared when present above 0.001% in leave-on products or 0.01% in rinse-off products as part of EU's 26 established contact allergens list


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Demonstrates significant auto-oxidation vulnerability with up to 30% degradation within 168 hours at neutral pH when air-exposed. Requires antioxidant protection, typically alpha-tocopherol at 200 ppm concentration.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases
  • Reducing agents

Safety

CIR Status
Not reviewed
Max tested
0%
Pregnancy
Caution
Sensitization risk High

Prohibited in EU/UK since March 2022 due to reproductive toxicity classification. US regulations defer to IFRA restrictions with complete prohibition in lip/oral products.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

This ingredient presents unacceptable safety risks due to reproductive toxicity and high sensitization potential, warranting complete avoidance in precision skincare formulations.


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