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Moumoujus

BUTYLENE CARBONATE.

Valuable CAS 4437-85-8 / SKIN CONDITIONING

A polar aprotic solvent that excels as both a penetration enhancer and stabilizing carrier for active ingredients. This versatile compound increases the bioavailability of lipophilic actives while simultaneously functioning as a humectant and viscosity modifier. Its unique ability to create low-water environments makes it particularly valuable for stabilizing oxidation-prone ingredients like vitamin C.

Summary

solvent penetration enhancer skin conditioning humectant viscosity modifier

Science

Mechanism of Action

Functions as a dual-action delivery system that enhances stratum corneum permeability while solubilizing lipophilic actives for improved penetration. Additionally provides humectant properties by attracting moisture to the skin surface and reduces formulation viscosity for enhanced spreadability.

Research

Clinical Evidence

Medium confidence
Effective range 0.3–25%
Optimal

5.5%

Key findings

  1. 01 Huntsman technical data demonstrates 1-10% range optimal for penetration enhancement in dermatological formulations
  2. 02 US Patent research confirms 0.3-25% concentration effectively stabilizes high-concentration ascorbic acid by preventing oxidation

Transparency

Dusting Analysis

Not commonly dusted

As a functional solvent and penetration enhancer used at meaningful concentrations, dusting is not applicable to this ingredient

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 5
0 7 14

Stability

Maintains structural integrity within pH 3-5 range but undergoes decomposition in extreme pH environments. Stable at ambient temperature yet vulnerable to hydrolysis under highly acidic or alkaline aqueous conditions.

Synergies

  • Ascorbic acid (stabilization)
  • Lipophilic actives (solubilization)

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
25%
Sensitization risk Low

Demonstrates low acute toxicity profile (Oral LD50 >5000 mg/kg) though classified as Category 2 eye irritant. Safety profile supported by structural similarity to CIR-approved Propylene Carbonate.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A multifunctional ingredient that enhances active delivery while providing stabilization benefits, particularly valuable in vitamin C formulations.

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