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Moumoujus

BUTYL PABA.

Avoid CAS 94-25-7 / UV ABSORBER

Butyl PABA is a synthetic compound that functions as both a UVB filter and topical anesthetic, historically used in sunscreen formulations and medical applications. This oil-soluble derivative of para-aminobenzoic acid absorbs ultraviolet radiation in the 286-310 nm range while providing mild numbing effects through sodium channel blockade. Despite its dual functionality, regulatory concerns have severely limited its cosmetic applications due to sensitization potential.

Summary

UV filter topical anesthetic

Science

Mechanism of Action

Functions through two distinct pathways: absorbs UVB radiation at peak wavelengths of 286-310 nm to prevent UV-induced skin damage, and blocks sodium ion permeability in neuronal membranes to inhibit nerve impulse conduction, creating localized anesthetic effects.

Research

Clinical Evidence

Medium confidence
Effective range ≤5%
Optimal

N/A

Key findings

  1. 01 In vitro permeation studies at 5.0% concentration demonstrated effectiveness as a lipophilic marker for evaluating skin barrier properties in human skin equivalent models
  2. 02 Research identifying significant sensitization potential leading to contact dermatitis and allergic reactions

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.1%

Regulatory restrictions and known sensitization issues make any detectable concentration concerning for consumer products.

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 7.4
0 7 14

Stability

Demonstrates stability in anhydrous systems and oil-in-water emulsions, particularly in acetate buffer systems at pH 5.0, but shows vulnerability to nitrosation reactions.

Conflicts

  • Strong oxidizing agents
  • Nitrosating agents
  • Strong acids

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Sensitization risk High

Prohibited in EU cosmetics under Annex II/167 regulation; FDA no longer recognizes PABA derivatives as GRASE for sunscreen applications due to safety concerns.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Avoid

Regulatory prohibitions and significant sensitization risks outweigh any potential cosmetic benefits.

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References

Sources