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BUTYL HYDROXYBUTYRATE.

Valuable CAS 53605-94-0 / SOLVENT

Butyl Hydroxybutyrate is a high-performance 'green' solvent derived from an aliphatic ester structure that serves as an eco-conscious alternative to harsh traditional solvents in skincare formulations. This EPA Safer Choice certified ingredient excels at enhancing product spreadability and facilitating the uniform delivery of active ingredients across the skin surface. With its low toxicity profile and biodegradable nature, it represents a sustainable approach to formulation optimization without compromising on performance.

Solvent Co-solvent Spreadability enhancer Active delivery facilitator

Science

As an aliphatic ester, this ingredient reduces formulation viscosity while simultaneously improving the solubility of challenging active compounds. It enhances the spreadability and sensory profile of emulsions by creating a more uniform distribution matrix, allowing for better penetration and delivery of co-formulated actives to the skin surface.


Research

Medium confidence
Effective range 1–10%
Optimal

10%

Key findings

  1. 01 Exhibited superior solvent efficiency in polymer dissolution while maintaining gentleness compared to conventional acetone-based systems

Transparency

Not commonly dusted

As a functional solvent ingredient rather than a marketing-driven active, dusting is not applicable to this component.


The Formula

Solubility
Both
Optimal pH 4.5 – 9
0 7 14

Stability

Maintains stability under standard storage conditions but may experience gradual hydrolysis in extreme pH environments below 3.0 or above 10.0. Exhibits excellent biodegradability and low volatility characteristics.

Synergies

  • Urea
  • Poorly soluble actives
  • Emulsion systems

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
10%
Pregnancy
Safe
Sensitization risk Low

EPA Safer Choice certified with oral and dermal LD50 >5000 mg/kg in rats. Pure substance classified as eye irritant under GHS, but safe at cosmetic use concentrations of 1-10%.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A scientifically-backed, environmentally conscious solvent that enhances formulation performance while maintaining an excellent safety profile across all skin types.


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References