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Moumoujus

BUTYL BUTYRATE.

Optional CAS 109-21-7 / PERFUMING

A multifunctional ester that serves as a lipophilic solvent and emollient in skincare formulations. Beyond its primary role in fragrance delivery and texture enhancement, emerging research suggests antimicrobial properties against acne-causing bacteria. This compound may also function as a precursor to skin-beneficial butyrate metabolites.

Summary

perfuming solvent emollient

Science

Mechanism of Action

Acts as a lipophilic carrier that enhances spreadability and provides non-greasy emolliency. Potentially metabolizes to butyrate, which can modulate skin immune responses and barrier function through HDAC inhibition and GPR109a receptor activation pathways.

Research

Clinical Evidence

Medium confidence
Effective range 14.4–15%
Optimal

15%

Key findings

  1. 01 Human maximization testing at 15% concentration showed no skin sensitization or irritation
  2. 02 At 14.4% in Pickering emulsions, demonstrated >97% reduction of C. acnes and S. aureus within 2 hours

Transparency

Dusting Analysis

Not commonly dusted

Primarily used as a functional ingredient rather than for marketing appeal, making dusting unlikely

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Moderate stability in slightly acidic to neutral conditions. Susceptible to hydrolysis in extreme pH environments and may undergo color changes during aging.

Synergies

  • Fragrance compounds
  • Oil-based actives

Conflicts

  • Oxidizing agents
  • Strong acids
  • Strong bases

Safety

Safety Profile

CIR Status
Safe as used
Max tested
15%
Pregnancy
Safe
Sensitization risk Low

RIFM-verified safety profile with FDA GRAS status for food use (21 CFR 172.515). Human patch testing confirms minimal sensitization potential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Optional

A well-tolerated multifunctional ingredient that excels in fragrance delivery and texture enhancement, with emerging antimicrobial benefits warranting further investigation.

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