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Moumoujus

BUTOXY PEG-4 PG-AMODIMETHICONE.

Valuable CAS 170274-77-8 / HAIR CONDITIONING

A water-soluble modified amino-silicone polymer engineered for gentle skin conditioning in aqueous formulations. This specialized silicone creates a breathable protective barrier that reduces friction damage while maintaining moisture balance without greasiness.

Summary

Skin conditioning Hair conditioning Film forming Emollient

Science

Mechanism of Action

Forms a vapor-permeable film on the stratum corneum that protects against frictional damage during cleansing while preventing transepidermal water loss. The butoxy PEG-4 PG modification enhances water compatibility and delivers conditioning benefits without occlusive heaviness.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–0.35%
Optimal

0.35%

Key findings

  1. 01 Human Repeat Insult Patch Test (RIPT) with 219 subjects at 0.5% showed no sensitization evidence
  2. 02 Rabbit dermal irritation study at 100% concentration demonstrated mild irritation (PII 1.80) but no primary irritant classification

Transparency

Dusting Analysis

Not commonly dusted

Not commonly used in dusting due to specialized water-soluble silicone nature and primary application in wet wipe formulations

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6
0 7 14

Stability

Demonstrates high stability in aqueous solutions, specifically designed for surfactant-based formulations

Synergies

  • Water-based cleansing systems
  • Mild surfactants

Conflicts

  • Strongly anionic surfactants due to potential complex formation from cationic amino-modification

Safety

Safety Profile

CIR Status
Not reviewed by CIR individually
Max tested
0.35%
Pregnancy
Safe
Sensitization risk Low

AICIS classified as safe for wet wipes at ≤0.35%. High molecular weight (>1,000 Da) results in poor skin penetration. LD50 >2000 mg/kg indicates low acute toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A well-tolerated, specialized conditioning agent ideal for water-based gentle cleansing formulations requiring non-greasy protection.

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References

Sources