Science
Mechanism of Action
Activates dermal fibroblast proliferation and accelerates extracellular matrix synthesis, including DNA, total protein, and collagen production at wound sites. Simultaneously reduces inflammation by inhibiting COX and LOX enzyme activity and suppressing pro-inflammatory cytokines like TNF-α, while bioactive flavonoids neutralize free radicals and prevent lipid peroxidation.
Research
Clinical Evidence
Medium confidence15%
Key findings
- 01 Human volunteers showed no irritation with 10-20% topical formulations after 48 hours (More et al., 2013)
- 02 Rat models demonstrated accelerated wound healing with increased cellular proliferation and collagen synthesis (Muralidhar et al., 2013)
Transparency
Dusting Analysis
Limited commercial presence in skincare makes dusting unlikely; traditional use and specific extraction methods suggest authentic inclusion when present
The Formula
Formulation
Stability
Maintains physical stability across 2°C to 37°C temperature range. Ethanol extraction yields both water-soluble and lipophilic phytochemicals for versatile formulation compatibility.
Synergies
- Other collagen-boosting peptides
- Complementary antioxidants
- Wound healing actives
Conflicts
- Strong oxidizing agents
- Highly alkaline environments above pH 7.0
Safety
Safety Profile
Listed in EU Cosmile database as skin-conditioning agent. Human patch testing at 20% concentration showed no primary irritation or sensitization responses.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A promising regenerative ingredient with documented wound healing benefits, though limited human clinical data restricts broader anti-aging claims.
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