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BURSERA SIMARUBA BARK EXTRACT.

Valuable CAS - / ANTIOXIDANT

Derived from the gumbo-limbo tree native to the Caribbean and Central America, this botanical extract delivers potent anti-inflammatory and antioxidant properties for reactive skin conditions. Rich in lignans, triterpenes, and flavonoids, it provides gentle yet effective soothing action while protecting against oxidative damage.

antioxidant soothing anti-inflammatory

Science

Functions through a multi-pathway approach, utilizing lignans (bursehernin, hinokinin), triterpenes, and flavonoids (quercetin, kaempferol) to neutralize reactive oxygen species and modulate inflammatory pathways, while demonstrating measurable immunosuppressive effects on T lymphocyte activity.


Research

Medium confidence
Effective range 2–4%
Optimal

4%

Key findings

  1. 01 Human patch testing at 4% showed non-irritant and non-sensitizing properties in 25 volunteers over 48 hours
  2. 02 DPPH radical scavenging assay demonstrated antioxidant efficacy with IC50 of 2.117 mg/mL
  3. 03 Animal studies confirmed anti-inflammatory activity comparable to phenylbutazone at 25 mg/kg

Transparency

Not commonly dusted

Limited commercial availability and specialized botanical sourcing make dusting unlikely; safety profile supports legitimate inclusion at effective concentrations.


The Formula

Solubility
Both
Optimal pH 4.5 – 7
0 7 14

Stability

Phenolic compounds require protection from oxidation; maximum stability achieved in slightly acidic conditions (pH 4.5-6.0) with light protection; methanolic extracts offer water compatibility while hexane extracts provide oil solubility

Conflicts

  • Strong oxidizing agents
  • Highly alkaline environments (may degrade phenolic content)

Safety

CIR Status
Not reviewed
Max tested
4%
Sensitization risk Low

Approved for cosmetic use in EU (CosIng) and US (FDA VCRP) databases; human testing confirms minimal irritation and sensitization potential at 4% concentration


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Well-researched botanical extract with proven anti-inflammatory and antioxidant benefits, particularly valuable for reactive and sensitive skin formulations.


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