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Moumoujus

BUDDLEJA GLOBOSA LEAF EXTRACT.

Valuable / SKIN CONDITIONING

A botanical extract derived from the leaves of Buddleja globosa, traditionally known as Matico, that demonstrates remarkable wound healing and skin repair properties. This polyphenol-rich extract combines potent antioxidant activity with fibroblast-stimulating capabilities to accelerate re-epithelialization and tissue regeneration. Its effectiveness at extremely low concentrations makes it an efficient active ingredient for targeted skin restoration formulations.

Summary

Skin Conditioning Soothing Antioxidant Wound Healing

Science

Mechanism of Action

Functions through multiple pathways including stimulation of dermal fibroblast proliferation and migration to facilitate collagen deposition and re-epithelialization. The extract's rich profile of phenylethanoid glycosides (particularly verbascoside), flavonoids (luteolin, quercetin), and iridoids provides broad-spectrum antioxidant protection by neutralizing reactive oxygen species and preventing DNA alkylation damage. Additionally modulates inflammatory response by regulating key markers including IL-6 and TNF-α.

Research

Clinical Evidence

High confidence
Effective range 0.001–10%
Optimal

0.005%

Key findings

  1. 01 Significantly enhanced human dermal fibroblast proliferation and migration at 12.5-50 µg/mL concentrations, critical for tissue repair processes
  2. 02 Exhibited potent free radical scavenging activity below 10 µg/mL, providing cellular protection from oxidative stress

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.001%
Red flag below
0.0005%

Given demonstrated efficacy at concentrations below 0.001%, any formulation containing less than 0.0005% should be considered potentially ineffective dusting rather than therapeutic dosing.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 5.5
0 7 14

Stability

Maintains optimal stability within slightly acidic pH range that complements skin's natural acid mantle. Polyphenolic compounds are vulnerable to degradation from excessive heat and light exposure, requiring protective packaging or encapsulation technology.

Synergies

  • Other antioxidants
  • Wound healing peptides
  • Hyaluronic acid

Conflicts

  • Strong oxidizing agents
  • High pH environments above 7.0

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Toxicological studies in animal models support topical safety even at concentrations exceeding typical commercial usage levels. In vitro cytotoxicity observed only at concentrations above 50 µg/mL, well beyond effective therapeutic range.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A scientifically-backed botanical extract with proven efficacy at remarkably low concentrations for skin repair and antioxidant protection.

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References

Sources