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BUDDLEJA DAVIDII LEAF EXTRACT.

Valuable CAS 94465-67-5 / SKIN CONDITIONING

A botanical extract derived from butterfly bush leaves that delivers comprehensive skin protection through phenylethanoid glycosides, particularly verbascoside and isoverbascoside. This multi-functional ingredient provides antioxidant defense, anti-inflammatory benefits, and matrix preservation while supporting natural wound healing processes.

antioxidant anti-inflammatory wound healing photoprotective skin conditioning

Science

Functions through high concentrations of phenylethanoid glycosides that neutralize free radicals and shield DNA from UV damage. Simultaneously inhibits key aging enzymes including matrix metalloproteinases, elastase, and hyaluronidase to preserve skin structure while suppressing inflammatory mediators IL-6 and TNF-alpha.


Research

High confidence
Effective range 25–200%
Optimal

0.2%

Key findings

  1. 01 Demonstrated 92.5% wound healing enhancement at 25 mg/L through accelerated cell migration
  2. 02 Achieved significant tyrosinase inhibition with IC50 of 38.17 mg/L for brightening effects
  3. 03 Confirmed anti-inflammatory activity at 200 mg/L with no cytotoxic effects on human skin cells

Transparency

Not commonly dusted
Min. effective
0.01%
Red flag below
0.005%

Efficacy demonstrated at meaningful concentrations starting from 25 mg/L, making dusting unlikely to provide therapeutic benefits


The Formula

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Maintains stability under standard conditions but requires protection from light, heat, and moisture to preserve bioactive glycosides

Synergies

  • Vitamin C
  • Niacinamide
  • Hyaluronic Acid

Conflicts

  • Strong acids
  • Strong bases
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed by CIR
Max tested
3%
Pregnancy
Safe
Sensitization risk Low

48-hour patch testing shows no irritation or sensitization. Non-cytotoxic to human skin cells at formulation-relevant concentrations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A well-researched botanical with proven multi-mechanism benefits and excellent safety profile across all skin types.


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