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Moumoujus

BUDDLEJA AXILLARIS LEAF EXTRACT.

Valuable CAS 608134-67-4 / ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

A botanically-derived active extracted from the leaves of Buddleja axillaris that delivers targeted pigmentation control through melanin transfer inhibition. This multifunctional ingredient combines brightening efficacy with anti-aging protection by preventing both UV-induced hyperpigmentation and collagen glycation damage.

Summary

antioxidant brightening skin conditioning skin protecting soothing

Science

Mechanism of Action

Operates through a triple-action pathway: inhibits Myosin-X protein expression to block melanin transfer from melanocytes to keratinocytes, prevents Advanced Glycation End-product formation that degrades collagen structure, and provides antioxidant protection via verbascoside and luteolin compounds against UVA-induced oxidative stress.

Research

Clinical Evidence

High confidence
Effective range 0.1–3%
Optimal

3%

Key findings

  1. 01 0.5% concentration significantly reduced UVA-induced pigmentation for 4 days in human volunteers
  2. 02 0.1% effectively suppressed AGE formation preventing collagen damage
  3. 03 10 μg/ml showed melanogenesis inhibition with zero cytotoxicity in melanocyte cultures

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Given demonstrated efficacy at 0.1% and manufacturer recommendations at 3.0%, concentrations below 0.05% would be insufficient for meaningful pigmentation benefits.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7
0 7 14

Stability

Maintains thermal stability up to 60°C with optimal long-term stability in neutral pH ranges; compatible with hydro-alcoholic systems

Synergies

  • vitamin C
  • niacinamide
  • alpha arbutin

Conflicts

  • strong oxidizing agents
  • extreme pH formulations

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
3%
Sensitization risk Low

Considered safe for cosmetic use based on manufacturer assessments and established use in East Asian cosmeceuticals, though formal CIR evaluation remains pending.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A well-researched botanical active with proven pigmentation control and anti-aging benefits at accessible concentrations.

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