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Moumoujus

BROUSSONETIA KAZINOKI BARK EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A botanical extract from the Korean paper mulberry tree that demonstrates impressive tyrosinase inhibition capabilities, outperforming kojic acid in melanin synthesis suppression. This multifunctional ingredient combines potent skin brightening effects with anti-inflammatory properties, making it particularly effective for treating hyperpigmentation and atopic skin conditions.

Summary

skin brightening anti-inflammatory antioxidant soothing skin conditioning

Science

Mechanism of Action

Functions as a dual-pathway active: inhibits tyrosinase enzyme through bioactive compounds Kazinol C and Kazinol F to reduce melanin production, while simultaneously suppressing inflammatory markers (IgE, IL-4, hTARC) via NF-kB and p38 MAPK pathway modulation. Additionally provides collagenase inhibition for anti-aging benefits.

Research

Clinical Evidence

High confidence
Effective range 0.02–0.1%
Optimal

0.05%

Key findings

  1. 01 87% inhibition of hTARC secretion at 0.05% concentration in keratinocyte cells
  2. 02 Superior atopic dermatitis lesion suppression vs 0.1% tacrolimus at 0.1% concentration
  3. 03 Dose-dependent tyrosinase inhibition with greater efficacy than kojic acid at 0.02-0.1%

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.01%
Red flag below
0.005%

Effective concentrations start at 0.02%, making sub-0.01% levels inadequate for therapeutic benefits. The significant difference between effective doses and trace amounts makes dusting detection straightforward.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Exhibits high sensitivity to thermal and photodegradation; active kazinol compounds require protection from temperatures exceeding 45°C and UV exposure. Microencapsulation recommended for enhanced stability.

Synergies

  • niacinamide
  • vitamin C
  • hyaluronic acid

Conflicts

  • high temperature processing
  • strong oxidizing agents
  • prolonged UV exposure

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

Generally recognized as safe in cosmetic applications with typical usage below 1% concentration. Safety profile supported by related botanical bark extract assessments.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A scientifically-backed botanical brightening agent that offers superior efficacy compared to traditional alternatives like kojic acid, with excellent tolerability across all skin types.

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