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BORAGE SEED OIL AMINOPROPANEDIOL AMIDES.

Valuable / SKIN CONDITIONING

Derived from borage seed oil, this ingredient conditions the skin, actively resolving inflammation. It supports robust barrier function and improves hydration, making it ideal for dry and irritated skin.

Skin Conditioning

Science

This ingredient resolves inflammation by increasing lipid pro-resolving mediators (e.g., resolvin RvD2) and decreasing pro-inflammatory cytokines (e.g., IL-1b). It also regenerates physical, microbiome, and immune skin barriers while enhancing ceramide quantity and diversity.


Research

High confidence
Effective range 0.005–1%
Optimal

N/A

Key findings

  1. 01 In vitro, 0.005% (v/v) significantly reduced pro-inflammatory cytokines (IL-1b, IL-6, IL-8, PGE2) and increased lipid pro-resolving mediators (resolvin RvD2, maresin 7(R) MaR1, lipoxins LxA4, LxB4).
  2. 02 In vivo, a 1% topical formulation improved skin conditions and demonstrated anti-inflammatory effects in subjects with psoriasis and atopic dermatitis.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Optimal pH range is not explicitly stated for this amide. Formulations may use pH adjusters, indicating pH is a stability consideration.


Safety

CIR Status
Insufficient data
Sensitization risk Low

While specific CIR data is limited, broader reviews for similar amides suggest safety when non-irritating. SkinSAFE rates it 'Teen SAFE', 'Baby SAFE', and 'Irritant Free', indicating a favorable profile.


Your Skin

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This ingredient is valuable for its potent anti-inflammatory and barrier-restoring effects, particularly beneficial for sensitive, dry, and compromised skin types.


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