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Moumoujus

BISABOLOL.

Essential CAS 515-69-5 / 23089-26-1 / FRAGRANCE, SKIN CONDITIONING, SOOTHING

Derived from chamomile, Bisabolol is a potent skin-calming active known for its anti-inflammatory, soothing, and moisturizing properties. It also effectively addresses hyperpigmentation and improves overall skin texture.

Summary

Antioxidant Soothing Anti-inflammatory Skin Conditioning Antimicrobial Moisturizing Penetration Enhancer Brightening

Science

Mechanism of Action

Bisabolol reduces inflammation and irritation by strengthening the skin barrier and acting as an antioxidant. It also offers antimicrobial benefits, improves pigmentation by inhibiting melanogenesis, and enhances the penetration of other active ingredients.

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 A 0.5% concentration showed a strong whitening effect on back skin after 8 weeks, indicating efficacy for hyperpigmentation.
  2. 02 Concentrations from 0.1-1.0% typically provide soothing, anti-inflammatory, and moisturizing benefits in cosmetic formulations.
  3. 03 An alpha-Bisabolol-based cream mitigated eczematous flares and improved eczema severity scores in children with atopic dermatitis.
  4. 04 It improved facial texture, skin oiliness, brightness, and hydration in melasma treatment when integrated into a formulation.
  5. 05 A 1% concentration was optimal for antimicrobial activity in facial skin hygiene solutions.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 2 – 12
0 7 14

Stability

Exhibits good stability across a wide pH range (2-12) and temperatures. Optimal addition is to the oil phase or during the cool-down phase (< 40°C) to prevent degradation.

Synergies

  • Enhanced effectiveness in attenuating pruritus and inflamed skin when combined with heparin.

Conflicts

  • Strong oxidizing agents may affect its stability.
  • Direct application to skin in pure form is not recommended and should be formulated.
  • Standard chamomile extracts, unlike purified Alpha-Bisabolol, may contain allergens causing irritation.
  • Poor quality active ingredients, alcohol, perfume, or essential oils in formulations can lead to irritation.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

Formulators should note Bisabolol's ability to increase skin penetration of other ingredients. FDA lists German chamomile, a source of alpha-bisabolol, as Generally Recognized as Safe (GRAS).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

A highly versatile and well-tolerated ingredient, Bisabolol is essential for calming irritation, promoting even skin tone, and enhancing overall skin health across all skin types.

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