Science
Mechanism of Action
SH-Pentapeptide-5 reduces expression lines via a 'Botox-like' effect by inhibiting acetylcholine release and promotes regeneration with EGF-like activity. Porphyra 334 absorbs UVA/UVB at ~334 nm, dissipates heat, and acts as a potent antioxidant to prevent photoaging and preserve collagen integrity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Porphyra 334 (40 µM) inhibited 56.2% MMP-1 mRNA expression in UV-A exposed human skin fibroblasts.
- 02 Porphyra 334 (1, 5, and 10 ppm) increased procollagen expression in Detroit 551 cells.
- 03 Topical/oral Porphyra 334 in UVB-irradiated mouse models significantly attenuated erythema, epidermal thickening, and oxidative stress, improving skin barrier without toxicity.
- 04 An in vivo study of a Gluthathione-CLA-SHPentapeptide-5 system demonstrated wrinkle lifting and skin firming when applied twice daily for one month.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Porphyra 334 is unstable in alkaline environments and prone to oxidation, maintaining relative stability in acidic conditions. Avoid repeated freeze-thaw cycles for stock solutions.
Conflicts
- Alkaline environments
- Oxidizing agents
Safety
Safety Profile
No specific CIR or SCCS assessment is available for this combined ingredient. Porphyra 334 showed no observable toxicity in mouse models and no cytotoxic effect below 200 µg/mL in 3T3-L1 cells.
Your Skin
Skin Compatibility
Our Assessment
Verdict
BIS-SH-PENTAPEPTIDE-5 PORPHYRA 334 is a valuable ingredient, offering multi-faceted benefits for wrinkle reduction, skin firming, and comprehensive photoprotection against UV-induced damage and oxidative stress.
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References
Sources