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BIS-HYDROXYETHYL TROMETHAMINE.

Valuable CAS 6976-37-0 / BUFFERING

BIS-HYDROXYETHYL TROMETHAMINE is a buffering agent derived from Tromethamine, primarily used to control and stabilize the pH of cosmetic formulations. It can also enhance polymer solubility and improve product rheological properties.

Summary

buffering

Science

Mechanism of Action

This ingredient functions by reacting with acidic components within a formula to form water-soluble salts, thereby neutralizing pH fluctuations. This action is crucial for maintaining the stability and optimal efficacy of pH-sensitive ingredients and overall product integrity.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 7.3 – 9.3
0 7 14

Stability

A component of 'Good's buffers', this ingredient offers good pH stability, effective within approximately ±1 pH unit of its parent compound's pKa of 8.3 at 20°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While the related compound Tromethamine is considered safe by CIR, BIS-HYDROXYETHYL TROMETHAMINE has not been specifically reviewed. GHS statements for the raw ingredient indicate it 'Causes skin irritation' and 'Causes serious eye irritation'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This potent buffering agent is valuable for maintaining optimal product pH and stability, though formulators must account for potential raw material irritation as per GHS statements.

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