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BIS-DIGLYCERYL POLYACYLADIPATE-2.

Essential CAS 82249-33-0 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

A high-performance, vegan alternative to lanolin that acts as a sophisticated lipid-replenishing agent. It provides exceptional moisture retention and barrier protection without the allergen risks associated with animal-derived ingredients.

substantive emollient occlusive film-former skin conditioner viscosity modifier

Science

This amphiphilic molecule features a glyceryl core that attracts water and long-chain fatty acids that seal it in. With a high molecular weight of approximately 1,200 g/mol, it stays on the skin's surface to form a breathable, non-penetrating occlusive shield that prevents transepidermal water loss.


Research

High confidence
Effective range 10–36%
Optimal

20%

Key findings

  1. 01 Demonstrated an impressive water-binding capacity of 170%–200% of its own weight, outperforming many traditional emollients in hydration longevity.
  2. 02 Proven to significantly enhance skin firmness and reduce TEWL (transepidermal water loss) when used at or above this threshold.
  3. 03 Confirmed as non-irritating and non-sensitizing in HRIPT testing, even at high inclusion rates in leave-on lip formulations.

Transparency

Not commonly dusted
Min. effective
10%
Red flag below
1%

While often used as a texture enhancer at lower levels, therapeutic barrier benefits for firmness and water loss reduction require concentrations of 10% or higher. Formulations using it only for label claims at sub-1% levels are effectively 'dusting'.


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Highly thermally stable with a melting point near skin temperature (35-39°C), facilitating a smooth application. It is resistant to oxidation and heat sterilization.

Synergies

  • Humectants like Glycerin
  • Ceramides
  • Plant oils

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Safe as used
Max tested
36%
Pregnancy
Safe
Sensitization risk Low

Its large molecular size prevents systemic absorption, making it an exceptionally safe topical choice for compromised barriers.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Essential

An elite, biocompatible barrier-builder that offers the moisture-trapping power of lanolin with superior purity and safety.


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