Science
Mechanism of Action
It functions as a selective inhibitor of the 11β-HSD1 enzyme, which is responsible for converting inactive cortisone into active cortisol within skin cells. By blocking this local cortisol production, it prevents stress-induced collagen breakdown, thinning of the epidermis, and barrier impairment.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 A 12-week clinical trial featuring 30 women aged 50-65 demonstrated that a 1% concentration significantly enhanced skin elasticity by 15.7% while visibly smoothing wrinkles and strengthening the moisture barrier.
- 02 In vitro analysis confirmed that 10 µM effectively halts the enzymatic conversion of stress hormones in both fibroblasts and keratinocytes.
Transparency
Dusting Analysis
Because it is typically supplied in a pre-diluted trade name solution (Bel-Even™), brands often claim its inclusion at 1% while the actual active molecule concentration is as low as 0.001%. For therapeutic results in stress-aging, the formulation should utilize the full 1% of the trade blend.
The Formula
Formulation
Stability
The molecule is heat stable up to 85°C; however, we recommend cool-down phase addition (below 40°C) to ensure peak molecular integrity. It is highly miscible with glycerin and glycols.
Synergies
- Ceramides
- Hyaluronic Acid
- Peptides
Conflicts
- No known chemical incompatibilities with standard cosmetic preservatives or sunscreens.
Safety
Safety Profile
Halal certified and approved for global use in major markets including the EU and USA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated precision ingredient that specifically addresses the biological pathway of stress-induced aging.
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