Science
Mechanism of Action
This peptide functions as a GHRP-mimetic, signaling the skin to initiate endogenous repair and protein synthesis. It specifically upregulates Collagen-XVII, Laminin-5, and Integrin-α6 to reinforce skin architecture while simultaneously promoting adipogenesis to counteract age-related volume loss.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Demonstrated stimulation of Type I Collagen and essential basement membrane proteins in human fibroblasts.
- 02 Shown to induce significant dermal thickening and activate repair-oriented paracrine factors (FGF2, FGF5) in 3D skin models.
- 03 Observed increase in pre-adipocyte differentiation to support facial lipofilling effects.
Transparency
Dusting Analysis
Due to its complex synthesis and high cost, this ingredient is frequently included at 'label-only' concentrations below 1%. For clinical dermal thickening and volume restoration, a minimum concentration of 1% is required.
The Formula
Formulation
Stability
Highly stable in acidic environments; sensitive to thermal degradation and should be incorporated during the cool-down phase below 40°C.
Synergies
- Hyaluronic Acid
- Other Signaling Peptides
- Niacinamide
Conflicts
- Strong oxidizing agents
- Alkaline environments (pH > 7.0)
- Proteolytic enzymes
Safety
Safety Profile
Safe profile consistent with other biotinylated signaling peptides; the trifluoroacetate salt is a standard stabilizer for peptide purity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated cell-communicating peptide that excels at restoring skin density and structural integrity when used at therapeutic concentrations.
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References
Sources