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BIOSACCHARIDE GUM-4.

Valuable CAS 905593-86-4 / SKIN CONDITIONING

A high-molecular-weight anionic polysaccharide that functions as a biological shield against modern environmental stressors. By creating a 'second skin' matrix, it provides a physical barrier that prevents pollutants from adhering to or penetrating the cutaneous layers.

anti-pollution agent film former skin conditioning barrier protection

Science

It constructs a non-occlusive, breathable film on the skin's surface. This physical mesh works via a three-way protection strategy: it blocks fine particulate matter (PM2.5), heavy metals, and carbon particles; it limits the impact of UV-induced damage; and it neutralizes domestic chemical aggressors. Furthermore, it regulates the inflammatory response by inhibiting the release of pro-inflammatory markers like IL-1α and PGE2.


Research

High confidence
Effective range 1–5%
Optimal

3%

Key findings

  1. 01 Clinical data indicates that a 5% concentration significantly attenuates the release of IL-1α and PGE2 in human epidermis models exposed to heavy metals and PM2.5.
  2. 02 In vivo testing at 1-3% demonstrates a measurable reduction in the adhesion of fine particulate matter to the skin and hair surfaces.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.5%

Because it is effective at low concentrations, brands often include it at trace amounts (<0.5%) for 'anti-pollution' marketing claims without providing the film-forming density required to actually block PM2.5 adhesion.


The Formula

Solubility
Water
Optimal pH 3 – 9
0 7 14

Stability

Highly stable across a broad pH range; typically supplied as an aqueous solution. Must be stored away from direct heat to maintain polysaccharide integrity.

Synergies

  • Antioxidants
  • Hyaluronic Acid
  • UV Filters

Conflicts

  • Cationic surfactants
  • Polyquaterniums
  • High concentrations of electrolytes/salts

Safety

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Classified as Generally Recognized as Safe (GRAS) and non-toxic for topical application by the CIR Expert Panel.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An essential shielding ingredient for urban skincare formulations requiring a physical, breathable defense against microscopic pollutants.


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