Science
Mechanism of Action
Functioning as a sophisticated postbiotic system, this ingredient delivers a spectrum of anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and anti-aging benefits. It precisely modulates the skin microbiota, favoring beneficial species and discouraging pathogenic growth. The Bifida Ferment Lysate component actively supports cellular recovery, provides robust antioxidant defense against environmental stressors, and helps shield cellular DNA from UV-induced damage. It improves skin smoothness by inhibiting protein-degrading enzymes (MMP3 and MMP9) linked to elasticity loss and wrinkle formation, while also reducing redness and suppressing immune-suppressive biochemicals following UV exposure. Concurrently, the Lactobacillus Ferment Lysate enhances skin barrier function and offers soothing effects. It measurably decreases transepidermal water loss (TEWL), mitigates redness, and boosts hydration by modulating skin's immune responses and stimulating antimicrobial peptide production. This complex blend's components, including hyaluronic acid, lactic acid, lipoteichoic acid, sphingomyelinase, and exopolysaccharides, collectively contribute to superior hydration, gentle exfoliation, reinforced barrier integrity, and comprehensive antioxidant protection.
Research
Clinical Evidence
Medium confidenceFormulations containing 10% Bifida Ferment Lysate have demonstrated significant improvements in skin elasticity, wrinkle reduction, and moisturizing effects over 4 weeks. In vitro tests show 5% Bifida Ferment Lysate stimulates gene expression vital for epidermal differentiation and barrier repair. Lactobacillus Ferment Lysate, when incorporated into formulations, is clinically shown to decrease TEWL, reduce redness, and improve hydration.
Key findings
- 01 Significant improvement in skin elasticity and reduction in wrinkles over 4 weeks. Significant moisturizing effect and reduction of transepidermal water loss (TEWL).
- 02 Stimulated expression of genes related to epidermal differentiation and skin barrier repairing in in vitro tests for Rejuvactor (Bifida Ferment Lysate).
- 03 Formulations containing Lactobacillus Ferment Lysate can decrease transepidermal water loss (TEWL), reduce redness, and improve skin hydration.
Transparency
Dusting Analysis
Given the significant clinical efficacy observed for its individual components at concentrations ranging from 5% to 10%, this ingredient is generally not considered a 'dusting' component. Efficacious levels are well-established, with concentrations below 1% likely indicating insufficient therapeutic benefit in a final product.
The Formula
Formulation
Stability
As a postbiotic blend, this ingredient demonstrates superior stability across a broad temperature and pH spectrum, offering a significantly extended shelf life compared to live probiotic formulations due to its lack of cell viability requirements.
Synergies
- Other postbiotics
- Prebiotics
- Hydrating agents (e.g., Hyaluronic Acid, Glycerin)
- Antioxidants
- Barrier-supporting lipids (e.g., Ceramides)
Safety
Safety Profile
While the exact combined ingredient has not undergone specific review by CIR or SCCS, its individual components are broadly recognized as safe for topical cosmetic use. Polysorbate 80 holds GRAS status. Bifida Ferment Lysate has demonstrated no ocular irritation at 100% concentration and no adverse skin effects in patch tests up to 30% concentration on human skin. Lactobacillus Ferment Lysate is also considered safe for topical application, exhibiting a low potential for irritation and sensitization. Postbiotics, in general, are lauded for their enhanced stability and safety profile compared to viable probiotics, crucially lacking the ability to transfer antibiotic resistance.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This postbiotic blend is a valuable ingredient for advanced skincare formulations, offering comprehensive benefits for skin barrier health, hydration, and anti-aging through its synergistic microbial components.
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