Science
Mechanism of Action
It functions as a sirtuin-1 (SIRT1) activator, stimulating cellular 'longevity enzymes' to protect and repair DNA. By promoting the synthesis of collagen and elastin while simultaneously inhibiting matrix metalloproteinases (MMPs), it prevents the enzymatic degradation of the skin’s scaffolding.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 Clinical trials of a proprietary complex containing this derivative demonstrated that 100% of subjects achieved visibly younger-looking skin, with 66% shifting their clinical skin age back by a full decade over 8 weeks.
Transparency
Dusting Analysis
Because this is a high-potency derivative typically found in proprietary complexes, concentrations below 0.1% may fail to trigger the SIRT1 activation necessary for visible age-reversal effects.
The Formula
Formulation
Stability
The amide linkage and PEG-44 modification provide excellent stability in aqueous formulas, eliminating the need for harsh alcohols or heavy oils usually required for triterpenoids.
Synergies
- Peptides
- Hyaluronic Acid
- Antioxidants
Conflicts
- Strong oxidizing agents
- High-acidity environments (pH < 4.0)
Safety
Safety Profile
While generally safe and low-irritancy, it is produced via ethoxylation, which may be a consideration for consumers strictly adhering to certain 'clean beauty' exclusionary lists.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-precision longevity molecule that offers measurable improvements in skin density and age-regression when formulated at active levels.
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References
Sources