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BETA-METHYL-CYCLODODECANEETHANOL.

Optional CAS 118562-73-5 / PERFUMING

Commonly known by the trade name Hydroxyambran, this sophisticated macrocyclic compound serves as a cornerstone in luxury aromatic formulations. It provides a multi-dimensional woody-amber scent profile while functioning as a structural anchor for more volatile scent molecules.

perfuming fragrance fixative

Science

This ingredient operates as a high-tenacity fragrance fixative by lowering the vapor pressure of accompanying aromatic compounds. On a molecular level, its lipophilic structure allows it to adhere to the skin's surface, ensuring a controlled, long-lasting release of fragrance notes over time.


Research

High confidence
Effective range 0.1–5%
Optimal

5%

Key findings

  1. 01 In vitro KeratinoSens testing confirmed the ingredient remains below the threshold for skin sensitization, demonstrating a safety profile superior to traditional allergens like Citral.
  2. 02 OECD 401 protocols identified an LD50 exceeding 10,000 mg/kg, classifying the material as having extremely low acute systemic toxicity.

Transparency

Not commonly dusted
Min. effective
0.5%
Red flag below
0.01%

In precision skincare, this ingredient is rarely 'dusted' because its primary role is aesthetic rather than biological. However, if used below 0.1%, it may fail to provide the intended fixative properties for the formula's scent profile.


The Formula

Solubility
Oil
Optimal pH 3 – 10
0 7 14

Stability

Exceptional chemical stability; it remains inert and effective in both highly acidic environments and alkaline conditions like saponified soaps.

Synergies

  • Volatile citrus oils
  • Essential oils
  • Lipid-based delivery systems

Conflicts

  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Regulated strictly by IFRA 49th Amendment standards. While safe for skin at diluted levels, the pure raw material is an eye irritant and environmental hazard for aquatic life.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A high-performance, stable fragrance fixative ideal for maintaining scent integrity in premium formulations without high sensitization risks.


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References