Science
Mechanism of Action
This peptide operates via a two-pronged pathway: it acts on muscarinic acetylcholine receptors (m-nAChR) to inhibit sodium uptake, effectively softening muscle contractions to reduce expression lines. Simultaneously, it activates the TGF-β signaling pathway to stimulate the synthesis of Collagen types I, III, IV, VII, and XVII while protecting existing fibers by inhibiting elastase activity.
Research
Clinical Evidence
High confidence10%
Key findings
- 01 In-vivo testing at 1% concentration demonstrated visible improvements in skin firmness and elasticity over a 63-day period.
- 02 Comparative in-vitro analysis showed the peptide outperforms Vitamin A and Palmitoyl Pentapeptide-4 in Collagen Type I synthesis following UV exposure.
- 03 Clinical data at 10% concentration confirmed an 'instant' anti-wrinkle effect within 15 to 120 minutes, surpassing the performance of Syn-Ake in reducing expression lines.
Transparency
Dusting Analysis
While structural firming begins at 1%, the high-performance 'Botox-like' instant effect requires a 10% concentration; products marketed for immediate results often use lower, 'dusted' amounts that only provide long-term benefits.
The Formula
Formulation
Stability
The molecule is heat-sensitive and must be incorporated during the cool-down phase at temperatures below 40°C. It demonstrates excellent electrolyte tolerance.
Synergies
- Hyaluronic acid
- Other signaling peptides
- UV-protective antioxidants
Conflicts
- Temperatures exceeding 40°C
- Highly acidic formulations (pH < 5.0)
- Strongly alkaline environments (pH > 7.0)
Safety
Safety Profile
Officially listed in China's IECIC as of 2025 after a successful three-year safety monitoring period as a New Cosmetic Ingredient (NCI).
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-precision peptide that offers a rare combination of immediate neuromuscular relaxation and documented long-term collagen up-regulation.
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