Science
Mechanism of Action
This ingredient functions as a selective Formyl Peptide Receptor 1 (FPR1) antagonist. By blocking these specific receptors, it inhibits the activation of neutrophils and prevents the release of Substance P—a primary neuropeptide responsible for neurogenic inflammation and skin sensitivity induced by external stressors.
Research
Clinical Evidence
High confidence0.02%
Key findings
- 01 Identified as a potent ligand for inhibiting neutrophilic inflammatory diseases and ROS production at 10 μM concentrations (Amorim et al., 2019).
- 02 Supplier data confirms efficacy between 0.001% and 0.05% for neutralizing neurogenic inflammation and reducing visible redness.
Transparency
Dusting Analysis
Because this peptide is physiologically active at exceptionally low concentrations (parts per million), it is rarely 'dusted' in the traditional sense; however, concentrations below 0.001% may lack the potency required to effectively inhibit the FPR1 pathway.
The Formula
Formulation
Stability
The methyl ester structure is prone to hydrolysis if exposed to extreme pH environments. It remains most stable within physiological skin pH ranges and should ideally be housed in anhydrous systems or stabilized emulsions shielded from light.
Synergies
- Bisabolol
- Allantoin
- Centella Asiatica
Conflicts
- Strong oxidizing agents
- Strong acids
- Strong bases
Safety
Safety Profile
Recognized by the EU Cosmetic Ingredient Database and PCPC. While CIR review is pending, current toxicological data suggests it is non-irritating and safe for topical use in precision skincare.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite, low-dose peptide that offers scientifically-backed relief for neurogenic inflammation and reactive skin types.
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