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Moumoujus

BAICALEIN.

Valuable CAS 314041-17-3 / SKIN CONDITIONING

A potent flavone polyphenol traditionally isolated from Scutellaria baicalensis, Baicalein serves as a multi-target bioactive that reinforces the skin’s defense against oxidative stress and photo-aging. It is highly regarded for its dual capacity to brighten the complexion and preserve structural proteins by neutralizing free radicals before they can trigger inflammatory cascades.

Summary

antioxidant soothing skin brightening photo-protection anti-glycation

Science

Mechanism of Action

Baicalein operates as a biological shield by inhibiting the NF-κB and MAPK signaling pathways, effectively suppressing pro-inflammatory responses. It functions as a tyrosinase inhibitor to downregulate melanin synthesis and acts as a specialized 12-lipoxygenase inhibitor to prevent lipid peroxidation. Additionally, it absorbs UV radiation at a molecular level, scavenging reactive oxygen species (ROS) to protect keratinocyte DNA from strand breaks and apoptosis.

Research

Clinical Evidence

High confidence
Effective range 0.1–0.5%
Optimal

0.5%

Key findings

  1. 01 A 60-day clinical evaluation of a Baicalein-rich complex demonstrated a 12.5% improvement in skin elasticity and a 13% reduction in the depth of established wrinkles.
  2. 02 Human Repeat Insult Patch Testing (HRIPT) confirmed that concentrations up to 0.5% are non-sensitizing and safe for leave-on applications.
  3. 03 In vitro studies at 20 µM concentrations showed significant protection against UVB-induced DNA damage and cellular death.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Because Baicalein is effective at very low concentrations, brands often include it at 'label-only' levels (below 0.05%) to claim antioxidant benefits without providing the 0.1-0.5% range required for significant elasticity and brightening results.

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 6
0 7 14

Stability

Highly susceptible to rapid oxidative degradation in alkaline environments (pH > 7.0). Stability is significantly improved through liposomal encapsulation or micellar delivery systems to prevent color shift and loss of potency.

Synergies

  • Vitamin E
  • L-Ascorbic Acid
  • Ferulic Acid
  • Liposomal delivery systems

Conflicts

  • Ferric ions (Iron)
  • Cupric ions (Copper)
  • Zinc ions
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.5%
Pregnancy
Safe
Sensitization risk Low

While generally non-toxic and soothing, individuals with known allergies to the Lamiaceae (mint) plant family should exercise caution.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A sophisticated, high-performance antioxidant that provides essential protection against photo-damage and loss of elasticity when formulated within its strict stability parameters.

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