Science
Mechanism of Action
The fermentation process via Bacillus subtilis acts as a molecular catalyst, breaking down complex 6-methoxyflavonols and polysaccharides into smaller molecules for deeper epidermal penetration. This synergy inhibits the NF-κB and MAPK signaling pathways to arrest inflammatory cascades while the volcanic ash component introduces vital trace minerals like zinc and magnesium to regulate sebum and catalyze skin repair.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Fermentation increases total polyphenol content by 1.3x and flavonoid concentration by 3.07x compared to non-fermented extracts.
- 02 Demonstrated significant inhibition of nitric oxide (NO) and proinflammatory cytokines at concentrations between 1.0% and 5.0%.
- 03 In vitro data confirms a marked reduction in skin irritation markers and accelerated barrier function recovery via MAPK pathway modulation.
Transparency
Dusting Analysis
With measurable in vitro efficacy starting as low as 0.1%, this ingredient is effective at modest concentrations; however, many formulations may use it below 0.1% simply for label claims, missing the 3.07x flavonoid boost found at higher therapeutic levels.
The Formula
Formulation
Stability
The filtrate is highly stable in aqueous systems but is thermolabile; it must be incorporated during the cooling phase (below 40°C) to prevent the degradation of bioactive fermentation metabolites.
Synergies
- Niacinamide
- Zinc PCA
- Hyaluronic Acid
- Probiotic Lysates
Conflicts
- Strong oxidizing agents
- Formulations with pH < 3.5 (potential mineral complex precipitation)
Safety
Safety Profile
Listed in the EU COSMILE database. The biocompatibility of the fermentation process typically renders the extract non-sensitizing and suitable for reactive skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated biotechnological active that provides multi-pathway soothing and mineral enrichment, making it an excellent choice for modern, microbiome-conscious skincare.
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