Science
Mechanism of Action
This ingredient functions through a dual-action pathway: it inhibits HYAL2 (hyaluronidase) enzymes to prevent the degradation of natural hyaluronic acid while simultaneously stimulating fibroblast vitality to accelerate collagen synthesis and dermal matrix repair.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Upregulation of hyaluronic acid content and enhanced epidermal barrier function at 2.0% concentration.
- 02 Significant increase in fibroblast activity and antioxidant protection observed within the 1.0-5.0% range.
Transparency
Dusting Analysis
Due to the cost of fermentation processes, brands often include this at sub-clinical levels (<1.0%). For therapeutic barrier repair and collagen support, a minimum of 2.0% is recommended.
The Formula
Formulation
Stability
Highly thermolabile; must be incorporated during the cooling phase at temperatures below 40°C to preserve enzymatic and peptide bioactivity.
Synergies
- Hyaluronic Acid
- Niacinamide
- Ceramides
- Non-acidic antioxidants
Conflicts
- Strong oxidizing agents
- Thermal processing >40°C
- Low pH environments <3.5
Safety
Safety Profile
Component parts (Soy, Rose, and Bacillus ferments) are well-characterized for safety; however, use levels in leave-on products are typically capped around 1.5% in standardized industry reporting.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance multifunctional ferment that bridges the gap between microbiome health and structural anti-aging.
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