Science
Mechanism of Action
The filtrate utilizes Nordihydroguaiaretic acid (NDGA) to selectively inhibit IGF-1 receptor tyrosine kinase activity within the hair follicle, effectively stalling the transition into the growth (anagen) phase. Simultaneously, the Bacillus-driven fermentation of soybean increases the bioavailability of isoflavones and probiotic metabolites, which fortify the moisture barrier and quell inflammatory responses.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 In-vivo trials using a 3% concentration demonstrated a 37% reduction in visible hair regrowth and a measurable decrease in hair diameter over a 28-day cycle.
- 02 Technical analysis confirms the inhibition of growth stimuli in hair matrix cells, delaying the anagen phase.
Transparency
Dusting Analysis
To achieve the documented hair-retardant effects, a concentration of at least 1-3% is required. Products listing this ingredient near the bottom of the INCI list may provide antioxidant benefits but likely lack the potency needed for hair growth inhibition.
The Formula
Formulation
Stability
Thermosensitive; must be incorporated during the cooling phase (below 40°C) to protect the integrity of the fermented metabolites.
Synergies
- Soothing agents
- Moisturizing factors
- Post-depilatory actives
Conflicts
- Strong acids (pH < 3.5)
- Strongly alkaline bases
- High ethanol concentrations (>70%)
Safety
Safety Profile
While the specific complex is not yet CIR-monographed, its individual components (Soybean and Larrea) have a long history of safe cosmetic use and are approved globally (EU CosIng/IECIC).
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional precision ingredient for post-hair removal care, offering scientifically-backed reduction in hair density alongside probiotic skin support.
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References
Sources